PyTorch Hub is an awesome new step forward in research reproducibility for machine learning and artificial intelligence. Makes it super easy to publish your pre-trained research models and for others to download them and test them. I was shocked how uncommon it was for people to publish their models when I first started reading machine learning papers.
An enzymatic pathway in the human gut microbiome that converts A to universal O type blood
This was a metagenomic study that identified two enzymes that may help convert A and B blood to O increasing the supply of blood available.
This is a cool ArXiv access point with upvoting and down voting, ability to save notes, see twitter commentary on paper and more.
Mapping human microbiome drug metabolism by gut bacteria and their genes
A fascinating look at how the microbiome may affect drug metabolism. Important to remember that the game does not end at pharmacogenomics and we need to be paying attention to the complex interplay of numerous complex systems to understand drug action.
Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer
Thanks to the ‘magic’ of deep learning we may be able to better predict which patients are going to respond to immunotherapy in gastrointestinal cancer with cheaper tests. More people treating their cancer certainly sounds good to me.
CCR5-∆32 is deleterious in the homozygous state in humans
The gene that was CRISPR-ed in those Chinese babies makes it more likely you die. This isn’t even accounting for the potential off-target effects. Turns out the thing we all knew was unethical is in fact unethical. Who da thunk?
Principles of and strategies for germline gene therapy
Following in the same vein as the previous article we take a theoretical look at the potential for these germline therapies.
The Sweetgreenification of Society
Interesting Substack post about the increasing stratification of society through the lens of boutique businesses.
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
From one, many. Our bodies are a huge mess of different mutations each of which could or could not be maybe contributing to diseases. Thinking of yourself as having one genetic identity is flawed.
A Jaunt Down Financial Fraud Lane
A fun article taking a look at some of the numerous scams in the cryptocurrency ecosystem. I am partial to the disaster that is EOS.
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This episode is all about starting to teach the basics of biochemistry. In this case we are looking directly at the glycolysis pathway. If you really don’t care about the underlying science feel free to skip this episode. Continue reading “Scientific Nutrition Update 25: Glycolysis”