Sunday Reads – Links I Found Interesting 6/9

Mapping human microbiome drug metabolism by gut bacteria and their genes

A fascinating look at how the microbiome may affect drug metabolism. Important to remember that the game does not end at pharmacogenomics and we need to be paying attention to the complex interplay of numerous complex systems to understand drug action.

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

Thanks to the ‘magic’ of deep learning we may be able to better predict which patients are going to respond to immunotherapy in gastrointestinal cancer with cheaper tests. More people treating their cancer certainly sounds good to me.

CCR5-∆32 is deleterious in the homozygous state in humans

The gene that was CRISPR-ed in those Chinese babies makes it more likely you die. This isn’t even accounting for the potential off-target effects. Turns out the thing we all knew was unethical is in fact unethical. Who da thunk?

Principles of and strategies for germline gene therapy

Following in the same vein as the previous article we take a theoretical look at the potential for these germline therapies.

The Sweetgreenification of Society

Interesting Substack post about the increasing stratification of society through the lens of boutique businesses.

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

From one, many. Our bodies are a huge mess of different mutations each of which could or could not be maybe contributing to diseases. Thinking of yourself as having one genetic identity is flawed.

A Jaunt Down Financial Fraud Lane

A fun article taking a look at some of the numerous scams in the cryptocurrency ecosystem. I am partial to the disaster that is EOS.

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